Apolipoprotein A-II

An extremely sensitive marker for the measurement of Apo A-II

Clinical Significance

Increased levels of Apo A-II appear to promote atherosclerosis by displacing Apo A-I in HDL and inhibiting reverse cholesterol transport.

Apolipoprotein A-II is a major constituent of High Density Lipoprotein (HDL) particles and plays an important role in reverse cholesterol transport and lipid metabolism. The distribution of Apo A-I in the HDL is primarily determined by the production rate of Apo A-II. Increased production of Apo A-II promotes atherosclerosis by decreasing the proportion of anti-atherogenic HDL containing Apo A-I.

Apo A-II is synthesised mainly in the liver and modulates lipoprotein lipase and hepatic triglyceride lipase. It also acts as a co-factor for Lecithin cholesterol acetyltransferase which is involved in lipoprotein processing.

Key Features of Randox Apolipoprotein A-II

 

Quality Control

Quality Control

 

Calibrators

 

Ordering information

LP3867R1 2 x 11mlR2 2 x 5ml

Applications are available for a large range of clinical chemistry analysers. Contact us for more information.


© 2018 Randox Laboratories Ltd. All rights reserved.