Apolipoprotein E

A highly accurate test for the measurement of Apo E

Clinical Significance

Apo E deficiency causes high serum cholesterol and triglyceride levels and leads to premature atherosclerosis.  Apo E has also been shown to affect the formation of atherosclerotic lesions by inhibition of platelet aggregation.

An APO E test is carried out to:

 

Apo E belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. These proteins also help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors and regulate the activity of enzymes involved in lipid metabolism. Apo E directs the lipoprotein to the correct site of metabolism. Apo E is a ligand for LDL and mediates the receptor binding of Apo E lipoproteins to the LDL receptor protein.

Defects in Apo E are a cause of hyperlipoproteinemia type III.  Apo E exists in three major isoforms: E2, E3 and E4, which differ from one another by a single amino acid substitution.  E3 is the most common isoform and is present in 77% of the Caucasian population.  Individuals heterozygous for E4 are associated with a higher risk for late onset Alzheimer’s disease.

Key Features of Randox Apolipoprotein E

 

Quality Control

Quality Control

 

Calibrators

 

Ordering information

LP3864R1 2 x 11mlR2 2 x 5ml

Applications are available for a large range of clinical chemistry analysers. Contact us for more information.


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